What question did this study set out to answer?

To compare 24-hour blood pressure patterns among women with healthy pregnancies, pregnancy-induced hypertension, preeclampsia, and chronic hypertension.

October 1, 1996Obstetrics and Gynecology

Blood Pressure Patterns in Normal Pregnancy and in Pregnancy-Induced Hypertension, Preeclampsia, and Chronic Hypertension

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Why the study?

Does 24-hour blood pressure monitoring reveal different circadian patterns among women with normal pregnancy, pregnancy-induced hypertension, preeclampsia, and chronic hypertension?

Population

212 women with singleton pregnancies, comprising 73 controls, 48 with pregnancy-induced hypertension, 38…

Comparison

24-hour blood pressure monitoring vs Comparison between physiologic pregnancy…

Design

Cohort

Authors

CBChiara BenedettoOspedale Sant'Anna

Discussion

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Implication

24h BP monitoring may distinguish PIH/preeclampsia by blunted rhythms from preserved patterns in chronic hypertension; leaves open prognostic value and prospective validation.

Key Points

To compare 24-hour blood pressure patterns among women with healthy pregnancies, pregnancy-induced hypertension, preeclampsia, and chronic hypertension.
Evaluated 212 women with singleton pregnancies across four groups: 73 healthy controls, 48 with pregnancy-induced hypertension, 38 with preeclampsia, and 53 with mild-to-moderate chronic hypertension.
Performed 24-hour blood pressure monitoring longitudinally in healthy controls and chronic hypertension cohorts, and at initial diagnosis in patients with pregnancy-induced hypertension or preeclampsia, yielding 19,872 total measurements.
Healthy controls demonstrated lower mean 24-hour blood pressure indices than established nonpregnant reference standards, with peak blood pressure (acrophase) consistently occurring during the early afternoon.
Circadian blood pressure oscillations were markedly blunted in pregnancy-induced hypertension and preeclampsia relative to hypertension severity, whereas patients with chronic hypertension preserved normal diurnal rhythms.

Structured PICO

Does 24-hour blood pressure monitoring reveal different circadian patterns among women with normal pregnancy, pregnancy-induced hypertension, preeclampsia, and chronic hypertension?

Population

212 women with singleton pregnancies, comprising 73 controls (physiologic pregnancy), 48 with pregnancy-induced hypertension, 38 with preeclampsia, and 53 with mild to moderate chronic hypertension.

Intervention

24-hour blood pressure monitoring (performed longitudinally in controls and chronic hypertension, and at diagnosis in pregnancy-induced hypertension and preeclampsia)

Comparator

Comparison between physiologic pregnancy (controls), pregnancy-induced hypertension, preeclampsia, and chronic hypertension

Outcome

24-hour blood pressure pattern (including mean values, circadian oscillations, and acrophase)surrogate

24-hour blood pressure monitoring reveals that pregnancy-induced hypertension and preeclampsia are associated with a loss of normal circadian BP rhythms, unlike chronic hypertension in pregnancy.

Cite This Study

Chiara Benedetto (1996) studied this question.

synapsesocial.com/papers/6a72c1a0f44fa9f079e01f24 https://doi.org/10.1016/0029-7844(96)00217-7

Topics

Hypertension management

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Implication

24h BP monitoring may distinguish PIH/preeclampsia by blunted rhythms from preserved patterns in chronic hypertension; leaves open prognostic value and prospective validation.

Blood Pressure Patterns in Normal Pregnancy and in Pregnancy-Induced Hypertension, Preeclampsia, and Chronic Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Blood Pressure Patterns in Normal Pregnancy and in Pregnancy-Induced Hypertension, Preeclampsia, and Chronic Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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