Prevention of Inflammation-Induced Endothelial Dysfunction
Why the study?
Does aspirin prevent inflammation-induced endothelial dysfunction in healthy volunteers?
Structured PICO
Does aspirin prevent inflammation-induced endothelial dysfunction in healthy volunteers?
P
Population
17 healthy volunteers (12 randomized to oral aspirin or placebo, 5 additional for intrabrachial aspirin) undergoing experimental inflammatory response generated by Salmonella typhi vaccination
I
Intervention
Aspirin 1.2 g orally 2 hours before vaccination (a separate cohort of 5 individuals received local intrabrachial aspirin 10 mg/min for 15 minutes)
C
Comparator
Placebo orally 2 hours before vaccination
O
Outcome
Resistance vessel responses to the endothelium-dependent dilator bradykinin (BK) and the endothelium-independent dilator glyceryl-trinitrate (GTN) assessed by venous occlusion plethysmography 16 hours before and 8 hours after vaccinationsurrogate
Pretreatment with high-dose oral aspirin prevents experimental inflammation-induced endothelial dysfunction, suggesting a potential mechanism for its cardiovascular protective effects beyond antiplatelet action.
Authors
Discussion
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Implication
Aspirin prevents experimental inflammation-induced endothelial dysfunction; extends mechanistic basis for its cardiovascular protection beyond antiplatelet effects.
Cite This Study
Kharbanda et al. (2002) studied this question.