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Background: Cartilage tissue has limited capacity for regenerationmainly due to its avascular nature. As a result, cartilagedeficiencies treatment has always been a difficult problemfor surgeons.Objectives: To evaluate the safety and effectiveness ofPRP and fat in cartilage grafting.Methods: This work was performed as a prospective manneron 20 young male New Zealand rabbits, each was an experimentalunit for three subcutaneous pockets for cartilage grafts(plus PRP in first pocket and Microfat in second one whilethe third one kept without any additives). Weight, volume, andhistopathology of inserted cartilage were evaluated after threemonths of insertion.Results: Revealed decrease in weight and volume of allcartilage grafts. The findings of histopathology revealed thatthe tissues of cartilages showing maximum degeneration andlosing of chondrocytes in intact cartilage without any additivesfollowed by cartilage injected with PRP while the tissues ofcartilages with fat showing minimum degeneration. The thicknessof the cartilage grafts injected with fat was the largestfollowed by cartilage with PRP and cartilage without any additivesrespectively.Conclusion: PRP and Microfat are suitable biologicalwrapping materials for grafting of the cartilage that increasesthe viability of the grafts. The use of fat on cartilage graftgives the best findings on the volume and weight measurementas well as histopathological score followed by cartilage graftwith PRP.
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Abdelazeem et al. (2024) studied this question.
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