Population
tsA201 cells expressing either wild type or C-terminal-truncated α1C subunits in combination with a β2a…
Comparison
Truncation of the α1C subunit and application of… vs Control, full-length α1C subunits
Design
Preclinical
Authors
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Supports potential C-terminal autoinhibition of L-type Ca2+ channels; leaves open relevance to native mammalian cardiac physiology.
C-terminal fragments of the α1C subunit can associate with C-terminal-truncated α1C subunits and inhibit currents through L-type Ca2+ channels, suggesting a regulatory role for these fragments in native tissues.
Gao et al. (2001) studied this question.
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