Why the study?
Does growth hormone replacement improve endothelial function and large-artery stiffness in GH-deficient adults?
Population
32 hypopituitary adults with growth hormone deficiency. 32 age- and sex-matched healthy controls were also…
Comparison
Growth hormone replacement over a 6-month period vs Placebo
Design
RCT, randomized, double-blind
Follow-up
6 months
Authors
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Supports GH replacement to mitigate CV risk in deficient adults; extends RCT evidence on vascular surrogates.
Does growth hormone replacement improve endothelial function and large-artery stiffness in GH-deficient adults?
Growth hormone replacement in GH-deficient adults significantly improves endothelial function and reduces large-artery stiffness, suggesting a potential reduction in cardiovascular risk.
Smith et al. (2002) studied this question.
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