⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

February 1, 1999The Journal of Clinical Endocrinology & MetabolismOpen Access

Growth Hormone (GH) Treatment Reverses Early Atherosclerotic Changes in GH-Deficient Adults1

View Full Paper

Ask AI

Bookmark

Share

Why the study?

Does recombinant human GH treatment reverse early morphological and functional atherosclerotic changes in GH-deficient adults?

Population

11 GH-deficient (GHD) hypopituitary men (24-49 yr old) and 12 age-matched control men (total n=23).

Comparison

Recombinant human GH for 18 months. vs 12 age-matched control men.

Design

Cohort

Follow-up

18 months

Authors

MPMarija PfeiferUniversity of Ljubljana RVRenata VerhovecUniversity of Ljubljana BŽBogomir ŽižekUniversity of Ljubljana

Discussion

Loading...

Member takes

Implication

GH treatment was associated with normalized carotid IMT and improved endothelial function in GH-deficient adults; leaves open effects on clinical events pending RCTs.

Structured PICO

Does recombinant human GH treatment reverse early morphological and functional atherosclerotic changes in GH-deficient adults?

P

Population

11 GH-deficient (GHD) hypopituitary men (24-49 yr old) and 12 age-matched control men (total n=23).

I

Intervention

Recombinant human GH (0.018 U/kg BW x day) for 18 months.

C

Comparator

12 age-matched control men (used for baseline comparison).

O

Outcome

Intima-media thickness (IMT) of the common carotid artery (CCA) and carotid bifurcation (CB), and flow-mediated endothelium-dependent dilation (EDD) of the brachial artery measured by B mode ultrasound at 3, 6, 12, and 18 months.surrogate

Growth hormone replacement in GH-deficient men reverses early morphological and functional atherosclerotic changes, potentially reducing vascular risk.

Cite This Study

Pfeifer et al. (1999) studied this question.

synapsesocial.com/papers/6a75b5bdae41e4ffbd6a3baa https://doi.org/10.1210/jcem.84.2.5456

View Full Paper

Ask AI

Bookmark

Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

1The effects of short and long-term growth hormone replacement therapy in hypopituitary adults on lipid metabolism and carbohydrate tolerance.1995 · 150 citations
2Regression or Progression1996 · 182 citations
3Discordant Effects of Dietary L-Arginine on Vascular Structure and Reactivity in Hypercholesterolemic Rabbits1995 · 43 citations
4The effect of growth hormone replacement on serum lipids, lipoproteins, apolipoproteins and cholesterol precursors in adult growth hormone deficient patients1994 · 151 citations