Why the study?
DOAC prescriptions at dosages non-adherent to labeling are common in practice; this study sought to identify baseline characteristics associated with non-recommended edoxaban dosing in South Korea and Taiwan.
What baseline characteristics are associated with non-recommended edoxaban dosing in patients with atrial fibrillation?
Population
2677 edoxaban-treated AF patients from South Korea and Taiwan
Comparison
Recommended vs non-recommended edoxaban dosing
Design
Observational study
Authors
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Baseline characteristics linked to off-label edoxaban dosing in East Asian AF patients merit caution; leaves open optimal dosing questions for trials.
What baseline characteristics are associated with non-recommended edoxaban dosing in patients with atrial fibrillation?
A significant proportion of atrial fibrillation patients receive non-recommended edoxaban dosing, often driven by physicians' consideration of clinical characteristics like bleeding risk and age.
Chao et al. (2021) studied this question.
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