Why the study?
Does imidapril prolong lifespan expectancy in cardiomyopathic hamsters?
Population
Cardiomyopathic (CM) hamsters of BIO 14.6 strain (a model of congestive heart failure)
Comparison
Imidapril administered in diet at 480 ppm or… vs Control hamsters receiving no imidapril
Design
Preclinical
Follow-up
Up to age 73 weeks
Authors
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Imidapril may prolong survival in this hamster model; leaves open translation to human heart failure.
Does imidapril prolong lifespan expectancy in cardiomyopathic hamsters?
Imidapril significantly prolongs the lifespan of cardiomyopathic hamsters, suggesting beneficial hemodynamic effects in this heart failure model.
Narita et al. (1996) studied this question.
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