Why the study?
Whether bedtime versus morning administration of antihypertensive therapy is beneficial on clinical outcomes is controversial.
Does evening or bedtime administration of antihypertensive therapy reduce total and cardiovascular mortality in treated hypertensive patients compared to morning administration?
Population
28 406 treated hypertensive patients in the Spanish ABPM Registry
Comparison
Evening or bedtime administration vs morning administration of antihypertensive medication
Design
Observational cohort study
Follow-up
Median of 9.7 years
Authors
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No mortality difference by dosing time in large registry; leaves open randomized confirmation of timing effects.
Does evening or bedtime administration of antihypertensive therapy reduce total and cardiovascular mortality in treated hypertensive patients compared to morning administration?
In a large observational cohort, the timing of antihypertensive medication (morning vs. evening) had no impact on all-cause or cardiovascular mortality.
Sierra et al. (2023) studied this question.
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