Alpha-1-adrenergic stimulation induces the S100B gene in cardiac myocytes via the PKC pathway, suggesting S100B acts as a negative feedback regulator of postinfarct myocardial hypertrophy.
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Hypothesis-generating for S100B as negative feedback regulator of postinfarct hypertrophy; requires human validation before any clinical consideration.
Tsoporis et al. (2003) studied this question.
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