Why the study?
Does overexpression of S100beta prevent norepinephrine-induced cardiac hypertrophy in a transgenic mouse model?
Population
Transgenic mice containing multiple copies of the human S100beta gene under the control of its own promoter…
Comparison
Norepinephrine intraperitoneally twice daily for… vs Vehicle intraperitoneally twice daily for 15 days
Design
Preclinical
Follow-up
15 days
Authors
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S100β overexpression may block norepinephrine-induced hypertrophy in mice; leaves open its role as a negative regulator in human disease.
Does overexpression of S100beta prevent norepinephrine-induced cardiac hypertrophy in a transgenic mouse model?
Overexpression of S100beta inhibits norepinephrine-induced cardiac hypertrophy in vivo and in vitro, suggesting it acts as an intrinsic negative regulator of the myocardial hypertrophic response.
Tsoporis et al. (1998) studied this question.
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