Why the study?
Does cigarette smoking impair endothelium-dependent vasodilatation and nitric oxide biosynthesis in healthy males?
Population
23 healthy male patients and an in vitro model using human umbilical vein endothelial cells
Comparison
Cigarette smoking and treatment of HUVECs with… vs Nonsmokers and treatment of HUVECs with serum…
Design
Cross-sectional
Authors
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Smoking-linked endothelial impairment supports reinforced cessation counseling; leaves open whether eNOS activity changes are causal or reversible.
Does cigarette smoking impair endothelium-dependent vasodilatation and nitric oxide biosynthesis in healthy males?
Cigarette smoking is associated with reduced endothelium-dependent vasodilatation and nitric oxide generation due to decreased eNOS activity, despite increased eNOS protein expression.
Barua et al. (2001) studied this question.
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