Why the study?
What is the frequency and trend of QTc prolongation associated with antipsychotic use in Asian patients with schizophrenia?
Population
3,482 hospitalized schizophrenia patients in six Asian countries and territories
Design
Cross-sectional
Authors
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Low QTc prolongation rates in Asian schizophrenia inpatients may not alter monitoring thresholds; leaves open targeted risk assessment for agents like thioridazine.
What is the frequency and trend of QTc prolongation associated with antipsychotic use in Asian patients with schizophrenia?
The frequency of QTc prolongation in Asian schizophrenia inpatients is relatively low (2.4%) and decreased between 2004 and 2008/2009, though specific antipsychotics like thioridazine carry higher risk.
Xiang et al. (2015) studied this question.
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