Why the study?
Elevated aortic stiffness and arterial hypertension occur in pediatric heart transplant patients, but data on pulse wave velocity in pediatric patients are limited.
Is pulse wave velocity abnormal in pediatric heart transplant recipients?
Is pulse wave velocity abnormal in pediatric heart transplant recipients?
Pediatric heart transplant recipients exhibit abnormal pulse wave velocity, a surrogate for arterial stiffness, both early and late post-transplantation.
Answers are grounded in this paper and cite their sources.
Abnormal PWV persists early and late after pediatric heart transplant; leaves open whether monitoring or interventions improve outcomes.
Elevated arterial stiffness is associated with an increased risk of comorbidities such as stroke, heart attack, and kidney disease. Pediatric heart transplant patients are known to have arterial hypertension and elevated aortic stiffness. Limited data on pulse wave velocity (PWV), a surrogate for arterial stiffness, is available in pediatric patients. We performed an observational, prospective study assessing arterial stiffness, utilizing PWV, in pediatric heart transplant recipients. Hemodynamic tracings were obtained via pigtail catheter pullback from ascending to descending aorta during surveillance cardiac catheterization. We found that PWV was abnormal ≥4m/s in patients early and late post-heart transplantation. Cholesterol levels were negatively correlated with PWV. A serial longitudinal assessment of PWV is required to further correlate abnormal PWV with clinical complications.
No takes yet. Share an insight, caveat, or question.
Coppola et al. (2025) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: