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January 1, 1971The Japanese Journal of PhysiologyOpen Access

A Study on the Excitation-Contraction Coupling of Thebullfrog Ventricle With Voltage Clamp Technique

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Population

Bullfrog ventricular trabeculae

Comparison

Voltage clamp depolarization with and without… vs Normal conditions and varying depolarization…

Design

Preclinical

Authors

MGMasayosi GOTOKyushu UniversityYKYosiko KIMOTOKyushu UniversityYKYuki KatoChiba University

Discussion

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Implication

Basic mechanisms in bullfrog ventricle warrant mammalian confirmation; leaves open direct clinical implications.

Structured PICO

P
Population
Bullfrog ventricular trabeculae
I
Intervention
Voltage clamp depolarization (varying durations and strengths) with and without tetrodotoxin
C
Comparator
Normal conditions and varying depolarization parameters
O
Outcome
Membrane potentials, currents, and contractile responses (tension development)surrogate

This basic science study elucidates the excitation-contraction coupling mechanisms in bullfrog ventricular myocardium, highlighting the dependence of tension development on depolarization duration.

Cite This Study

GOTO et al. (1971) studied this question.

synapsesocial.com/papers/6a72c32184cc45bb7be02a85https://doi.org/10.2170/jjphysiol.21.159
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The kinetics of mechanical activation in frog muscle1969 · 230 citations
  2. 2Membrane depolarization as a cause of tension development in mammalian ventricular muscle1959 · 118 citations
  3. 3Voltage clamp experiments on ventricular myocardial fibres1970 · 255 citations
  4. 4Inotropic Effects of Electric Currents1969 · 305 citations
  5. 5Membrane calcium current in ventricular myocardial fibres1970 · 399 citations