January 1, 1974The Japanese Journal of PhysiologyOpen Access

Effects of Osmolarity Change on the Excitation-Contraction Coupling of Bullfrog Ventricle

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Population

Bullfrog ventricle

Design

Preclinical

Authors

HKHiroshi KawataHigh Energy Accelerator Research Organization KKKimie KAWAGOEFukuoka University ITIwao TATEYAMAKyushu University

Discussion

Member takes

Implication

Osmolarity-sensitive calcium regulation in amphibian ventricle; hypothesis-generating for mammalian excitation-contraction coupling studies.

Structured PICO

Population

Bullfrog ventricle

Intervention

Hypertonic solutions (up to 400% tonicity with sucrose, up to 300% with NaCl) and hypotonic solutions (33.3% and 12.5%)

Outcome

Electrical (action potential duration) and mechanical (contractile tension) activitiessurrogate

Osmolarity changes significantly affect the excitation-contraction coupling of bullfrog ventricular muscle, indicating a superficial site for calcium regulation sensitive to osmolarity.

Cite This Study

Kawata et al. (1974) studied this question.

synapsesocial.com/papers/6a7c3137487e1f6bb31f6e54 https://doi.org/10.2170/jjphysiol.24.587

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Implication

Osmolarity-sensitive calcium regulation in amphibian ventricle; hypothesis-generating for mammalian excitation-contraction coupling studies.

Effects of Osmolarity Change on the Excitation-Contraction Coupling of Bullfrog Ventricle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of Osmolarity Change on the Excitation-Contraction Coupling of Bullfrog Ventricle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider