Why the study?
Does uraemia without hypertension impair cardiac structure or function in apoE-deficient mice?
Does uraemia without hypertension impair cardiac structure or function in apoE-deficient mice?
Uraemia without hypertension does not impair cardiac structure or function in apoE-deficient mice, suggesting that accompanying hypertension is a key driver of left ventricular disease in uraemia.
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Suggests hypertension is required for uraemic cardiomyopathy in this model; hypothesis-generating and does not support practice change.
Bro et al. (2008) studied this question.
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