Population
Voltage-dependent K+ channels (Shaker B and NGK2)
Comparison
Chimeric exchanges and point mutations in H5… vs Wild-type host channels (ShB and NGK2)
Design
Preclinical
Authors
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Basic science result in animal K+ channels warrants clinical caution; leaves open mosaic pore relevance to human channelopathies or therapies.
The pore properties of voltage-dependent K+ channels are determined by a polysegmental mosaic structure involving H5, S6, and post-S6 regions.
Taglialatela et al. (1994) studied this question.
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