July 29, 1991FEBS Letters

Molecular basis for different rates of recovery from inactivation in the Shaker potassium channel family

View Full Paper

Ask AI

Bookmark

Population

Shaker K+ channels

Comparison

Alanine/valine amino acid replacement within the… vs Alternative carboxyl-termini

Design

Preclinical

Authors

Discussion

Advances molecular understanding of Kv channel gating; leaves open relevance to human cardiac electrophysiology.

Population

Shaker K+ channels

Intervention

Alanine/valine amino acid replacement within the Shaker carboxyl-terminus at a site within the proposed membrane spanning segment S6

Comparator

Alternative carboxyl-termini

Outcome

Rates of inactivation and of recovery from channel inactivationsurrogate

Identifies the specific amino acid replacement responsible for different rates of recovery from inactivation in Shaker potassium channels.

Wittka et al. (1991) studied this question.

View Full Paper

Ask AI

Bookmark