Population
Xenopus oocytes injected with mRNAs encoding voltage-dependent potassium channels (RBK1, RGK5, and RBK2)
Comparison
Extracellular tetraethylammonium application and… vs Wild-type channels and channels with different…
Design
Preclinical
Authors
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May guide selective K+ channel blocker design; leaves open human translation and therapeutic relevance.
The study identifies specific amino acid residues, particularly Tyr379 in RBK1, in the external mouth of voltage-dependent potassium channels that determine sensitivity to tetraethylammonium via nonionic forces.
Kavanaugh et al. (1991) studied this question.
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