Population
CHO cells expressing wild-type KCNQ1-4 channels and heteromeric KCNQ2/3 channels (wild-type or mutant T323Y)
Design
Preclinical
Authors
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Varying TEA sensitivity across KCNQ isoforms implicates non-tyrosine residues; leaves open their utility for selective channel modulation in research.
The intermediate TEA sensitivity of KCNQ1 and KCNQ4 suggests that residues other than the tyrosine downstream of the pore signature sequence are important in determining TEA block of KCNQ channels.
Hadley et al. (2000) studied this question.
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