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June 30, 2025MedicinaOpen Access

Obesity (OR 2.481, 95% CI 1.49-4.12, p<0.001) and chronic hypertension (OR 2.813, 95% CI 1.44-5.49, p=0.002) were significant risk factors for fetal-neonatal complications.

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Why the study?

Gestational diabetes mellitus impacts maternal and fetal health, motivating assessment of the prevalence and risk factors for maternal and fetal-neonatal complications compared with women without GDM or with pre-existing diabetes.

Does gestational diabetes mellitus increase the risk of maternal and fetal-neonatal complications compared to non-diabetic pregnancies or pre-existing diabetes?

Population

1418 pregnant women

Comparison

GDM vs control (pregnant women without GDM) vs T1DM vs T2DM

Design

Retrospective observational study

Authors

AGAdriana GherbonMFMirela FrandeșCTCorina Dalia Toderescu

Discussion

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Overview

Higher GDM complication rates support enhanced surveillance; retrospective data leave open causal links and optimal interventions.

Structured PICO

Does gestational diabetes mellitus increase the risk of maternal and fetal-neonatal complications compared to non-diabetic pregnancies or pre-existing diabetes?

P
Population
1,418 pregnant women from Romania, including 279 with gestational diabetes mellitus (GDM), 74 with type 1 diabetes mellitus (T1DM), 107 with type 2 diabetes mellitus (T2DM), and 958 controls without GDM.
I
Intervention
Gestational diabetes mellitus (GDM)
C
Comparator
Pregnant women without GDM (control group), and pregnant women with T1DM or T2DM
O
Outcome
Maternal and fetal-neonatal complications (including abortion, pregnancy-induced hypertension, macrosomia, premature birth, APGAR score <7 at 5 min, and fetal mortality)composite

Obesity and chronic hypertension are significant independent risk factors for maternal and fetal-neonatal complications in pregnant women.

Cite This Study

Gherbon et al. (2025) studied this question.

synapsesocial.com/papers/6a72caa084cc45bb7be02d5fhttps://doi.org/10.3390/medicina61071190
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