What question did this study set out to answer?

Compare acute thrombogenicity and early vascular healing between thin-strut metallic biodegradable polymer drug-eluting stents and thick-strut fully bioabsorbable scaffolds.

May 29, 2015Circulation Cardiovascular InterventionsOpen Access

Thrombogenicity and Early Vascular Healing Response in Metallic Biodegradable Polymer-Based and Fully Bioabsorbable Drug-Eluting Stents

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Compare acute thrombogenicity and early vascular healing between thin-strut metallic biodegradable polymer drug-eluting stents and thick-strut fully bioabsorbable scaffolds.
Evaluated acute platelet aggregation across thin-strut metallic everolimus-eluting stents (EES), thick-strut bioabsorbable EES, thick-strut metallic biolimus-eluting stents, and control bare metal stents using an ex-vivo porcine arterio-venous shunt model.
Assessed vascular healing, endothelial maturity, and inflammatory cell adhesion (CD14/PM-1, RAM-11) in a healthy rabbit iliofemoral stent implantation model at 14 and 28 days.
Analyzed platelet adhesion and endothelial coverage using confocal microscopy and scanning electron microscopy.
Thin-strut metallic EES demonstrated significantly lower acute thrombogenicity compared with both thick-strut bioabsorbable EES and biolimus-eluting stents.
Metallic EES showed greater re-endothelialization at 28 days and reduced monocyte/macrophage adhesion at 14 days compared to bioabsorbable EES.
Control bare metal stents were the only devices to achieve complete re-endothelialization at 28 days.

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Implication

Preclinical comparative study demonstrates reduced thrombogenicity and faster vascular healing with metallic drug-eluting stents over bioabsorbable scaffolds, suggesting extended blood-thinner...

Cite This Study

Koppara et al. (2015) studied this question.

synapsesocial.com/papers/6a72cb5d8031ec7bb1dd7e8a https://doi.org/10.1161/circinterventions.115.002427

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Implication

Preclinical comparative study demonstrates reduced thrombogenicity and faster vascular healing with metallic drug-eluting stents over bioabsorbable scaffolds, suggesting extended blood-thinner...

Thrombogenicity and Early Vascular Healing Response in Metallic Biodegradable Polymer-Based and Fully Bioabsorbable Drug-Eluting Stents

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Discussion

Implication

Cite This Study

Thrombogenicity and Early Vascular Healing Response in Metallic Biodegradable Polymer-Based and Fully Bioabsorbable Drug-Eluting Stents

Key Points

Discussion

Implication

Cite This Study

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