April 28, 2026Journal of the American College of Cardiology
Pathology of Drug-Eluting Stents in Humans
Key result
DES linked to ~38% less endothelialization and greater delayed healing vs BMS.
- P=0.0001
- n=48
Why the study?
Data suggested the window of thrombotic risk for DES extends far beyond that for BMS, prompting evaluation of long-term arterial healing and mechanisms underlying late stent thrombosis.
Population
23 autopsy cases with DES duration >30 days and 25 matched BMS autopsy cases
Comparison
DES >30 days duration vs matched BMS implantation
Design
Registry-based autopsy case-control study
Authors
Discussion
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Member takes
Implication
Raises concern for late thrombosis after DES; leaves open safety of abbreviated DAPT with newer platforms.
Study Design
Type
Observational (n=48)
PICO
P
Population
Coronary artery disease with stent implantation (n=48)
I
Intervention / Comparator
Drug-eluting stents (Cypher and Taxus) vs Bare-metal stents
O
Primary Outcome
Endothelialization, p=0.0001
Main Result
Absolute Event Rate: 55.8% vs 89.8%
p-value: p=0.0001
Cite This Study
Joner et al. (2006) conducted an observational in Coronary artery disease with stent implantation (n=48). Drug-eluting stents (Cypher and Taxus) vs. Bare-metal stents was evaluated on Endothelialization (p=0.0001). Drug-eluting stents showed poorer endothelialization (55.8% vs 89.8%, p=0.0001) and greater delayed healing compared with bare-metal stents of similar implant duration.