Why the study?
What are the primary histological and morphometric predictors of late stent thrombosis in drug-eluting stents?
What are the primary histological and morphometric predictors of late stent thrombosis in drug-eluting stents?
Incomplete endothelial coverage and heterogeneity of healing are the primary pathological drivers of late stent thrombosis in drug-eluting stents.
Endothelial coverage metrics may refine DES thrombosis risk models; leaves open prospective validation in clinical cohorts.
The most powerful histological predictor of stent thrombosis was endothelial coverage. The best morphometric predictor of LST was the ratio of uncovered to total stent struts. Heterogeneity of healing is a common finding in drug-eluting stents with evidence of LST and demonstrates the importance of incomplete healing of the stented segment in the pathophysiology of LST.
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Finn et al. (2007) studied this question.
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