Population
isolated canine coronary artery rings
Design
Preclinical
Authors
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ET-1 may mediate coronary contraction via PI hydrolysis and Ca2+ uptake in canines; leaves open translation to human vasomotor disease.
Endothelin-1 stimulates phosphatidylinositol hydrolysis and calcium uptake as early events preceding maximal contractile response in canine coronary arteries.
Pang et al. (1989) studied this question.
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