What question did this study set out to answer?

The study aims to determine the roles of sympathetic nerves and adrenal hormones in circulatory control during hypoxia.

May 1, 1966The Journal of PhysiologyOpen Access

Circulatory control in hypoxia by the sympathetic nerves and adrenal medulla

View Full Paper

Ask AI

Bookmark

Population

Unanaesthetized normal rabbits, and animals subjected to adrenalectomy, 'sympathectomy', adrenalectomy +…

Comparison

Severe arterial and primary tissue hypoxia vs Different states of adrenergic effector pathways

Design

Preclinical

Authors

PKPaul KörnerAgile Therapeutics (United States)SWS. W. WhiteHunter Medical Research Institute

Discussion

Member takes

Implication

Sympathetic predominance in rabbit hypoxia is hypothesis-generating; leaves open translation to human circulatory responses.

Key Points

The study aims to determine the roles of sympathetic nerves and adrenal hormones in circulatory control during hypoxia.
Studied normal rabbits and those with adrenalectomy, sympathectomy, and nerve section.
Analyzed cardiac output, arterial pressures, heart rate, and ventilation under hypoxic conditions.
Compared responses during arterial and primary tissue hypoxia.
Sympathetic nerves were more crucial for maintaining circulatory response compared to adrenal hormones.
Animals with intact chemoreceptors tolerated hypoxia better, producing more peripheral vasoconstriction through sympathetic control.
Adrenalectomized and sympathectomized animals experienced decreased cardiac output over time during prolonged hypoxia.

Structured PICO

Population

Unanaesthetized normal rabbits, and animals subjected to adrenalectomy, 'sympathectomy' (guanethidine), adrenalectomy + 'sympathectomy', and section of the carotid sinus and aortic nerves

Intervention

Severe arterial and primary tissue (carbon monoxide) hypoxia

Comparator

Different states of adrenergic effector pathways (normal vs adrenalectomy vs sympathectomy vs both vs denervation)

Outcome

Cardiac output, arterial and right atrial pressures, heart rate and ventilationsurrogate

Sympathetic nerves are more critical than adrenal medullary hormones for circulatory control during severe hypoxia in rabbits.

Cite This Study

Körner et al. (1966) studied this question.

synapsesocial.com/papers/6a72d0691ed5c01da73dadf3 https://doi.org/10.1113/jphysiol.1966.sp007915

View Full Paper

Ask AI

Bookmark

Circulatory control in hypoxia by the sympathetic nerves and adrenal medulla

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Circulatory control in hypoxia by the sympathetic nerves and adrenal medulla

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider