Why the study?
Do KCNN4 blockers reduce brain oedema and infarct volume in experimental traumatic brain injury?
Population
C6BU1 rat glioma cells (in vitro) and rat acute subdural haematoma model (in vivo)
Design
Preclinical
Follow-up
up to 7 days
Authors
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Supports KCNN4 blockade in experimental TBI; leaves open clinical translation.
Do KCNN4 blockers reduce brain oedema and infarct volume in experimental traumatic brain injury?
Blockade of KCNN4 channels shows potent neuroprotective efficacy and reduces brain oedema in experimental traumatic brain injury.
Mauler et al. (2004) studied this question.
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