Independent activation of distinct pores in dimeric TMEM16A channels

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Population

TMEM16A channels (Ca2+-activated Cl- channels)

Comparison

Expression of TMEM16A channels constituting two… vs Wild-type TMEM16A channel

Design

Preclinical

Authors

Discussion

Informs TMEM16A dimer pore function; leaves open cardiovascular relevance pending functional validation.

Population

TMEM16A channels (Ca2+-activated Cl- channels)

Intervention

Expression of TMEM16A channels constituting two covalently linked subunits with different Ca2+ affinities and pore mutations

Comparator

Wild-type TMEM16A channel

Outcome

Pore architecture and activation mechanism (assessed via dose-response curves, FRET, and I-V curve rectification)

TMEM16A channels likely adopt a double-barrel pore architecture where each subunit activates independently.

Jeng et al. (2016) studied this question.

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