Why the study?
Does plasma BNP level accurately reflect left ventricular wall stress in obese individuals with chronic heart failure or angina pectoris?
Population
136 hospital inpatients with chronic heart failure or who had undergone a thorough examination for angina…
Comparison
Obesity (BMI ≥ 25) vs Nonobese (BMI < 25)
Design
Cross-sectional
Authors
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BNP may not reflect LV wall stress in obese patients; hypothesis-generating for altered biomarker utility pending prospective validation.
Does plasma BNP level accurately reflect left ventricular wall stress in obese individuals with chronic heart failure or angina pectoris?
Plasma BNP levels do not accurately reflect left ventricular wall stress in obese individuals, suggesting that BNP should be interpreted with caution as a marker of heart failure severity in this population.
Tosa et al. (2009) studied this question.
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