February 13, 2009Circulation ResearchOpen Access

Bosentan Enhances Viral Load via Endothelin-1 Receptor Type-A–Mediated p38 Mitogen-Activated Protein Kinase Activation While Improving Cardiac Function During Coxsackievirus-Induced Myocarditis

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Why the study?

Does bosentan improve cardiac function and alter viral load in a mouse model of coxsackievirus B3-induced myocarditis?

Population

Mouse model of coxsackievirus B3 (CVB3)-induced myocarditis

Comparison

Bosentan or SB203580 HCl vs Control group

Design

Preclinical, Blinded cardiac histopathologic scores

Authors

DMDavid MarchantUniversity of Alberta YDYing DouUniversity of British Columbia HLHonglin LuoCentral South University

Discussion

Member takes

Implication

Warrants caution with bosentan in infectious myocarditis; leaves open net benefit of endothelin antagonism in viral heart disease.

Structured PICO

Does bosentan improve cardiac function and alter viral load in a mouse model of coxsackievirus B3-induced myocarditis?

Population

Mouse model of coxsackievirus B3 (CVB3)-induced myocarditis

Intervention

Bosentan or SB203580 HCl (p38 MAPK inhibitor at 3 mg/kg or 10 mg/kg)

Comparator

Control group

Outcome

Cardiac function (ejection fraction and fractional shortening) and cardiac viral loadsurrogate

While bosentan improves cardiac function in viral myocarditis, it enhances viral load and disease severity via p38 MAPK activation, indicating caution for its use in infectious myocarditis.

Cite This Study

Marchant et al. (2009) studied this question.

synapsesocial.com/papers/6a72d75a2fdcb5703edb9d0e https://doi.org/10.1161/circresaha.108.191171

Topics

Myocarditis

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Bosentan Enhances Viral Load via Endothelin-1 Receptor Type-A–Mediated p38 Mitogen-Activated Protein Kinase Activation While Improving Cardiac Function During Coxsackievirus-Induced Myocarditis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Bosentan Enhances Viral Load via Endothelin-1 Receptor Type-A–Mediated p38 Mitogen-Activated Protein Kinase Activation While Improving Cardiac Function During Coxsackievirus-Induced Myocarditis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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