Why the study?
Does chronic endothelin receptor blockade with bosentan improve hemodynamics and attenuate ventricular dilation in rats with myocardial infarction?
Population
Rats with myocardial infarction (induced by coronary ligation) or sham operation
Comparison
Bosentan (mixed ET and ET receptor blocker) 100… vs Placebo
Design
Preclinical
Follow-up
8 weeks
Authors
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Supports testing endothelin blockade post-MI; leaves open translation to human heart failure outcomes.
Does chronic endothelin receptor blockade with bosentan improve hemodynamics and attenuate ventricular dilation in rats with myocardial infarction?
Chronic endothelin receptor blockade with bosentan attenuates progressive left ventricular dilation and improves hemodynamics in a rat model of myocardial infarction.
Fraccarollo et al. (1997) studied this question.
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