Why the study?
Does bosentan prevent acute myocardial remodeling and functional deficits in rats with chronic volume overload?
Population
Rats with chronic volume overload induced by aortocaval fistula
Comparison
Bosentan (100 mg/kg/day) vs Untreated fistula and sham-operated animals
Design
Preclinical
Follow-up
Up to 14 days
Authors
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Hypothesis-generating in rat volume-overload model; leaves open clinical translation of ET-1 antagonism.
Does bosentan prevent acute myocardial remodeling and functional deficits in rats with chronic volume overload?
Nonselective ET-1 antagonism with bosentan prevents acute increases in cardiac mast cell density and MMP activation, attenuating ventricular dilatation in a rat model of chronic volume overload.
Murray et al. (2008) studied this question.
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