Why the study?
Does endothelin-1 mediate cardiac mast cell degranulation and matrix metalloproteinase activation in isolated rat hearts?
Population
Blood-perfused isolated rat hearts
Comparison
Endothelin-1 20 pg/ml administration vs Control
Design
Preclinical
Authors
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ET-1 may promote edema and MMP-driven remodeling in rat hearts; hypothesis-generating for its role in human cardiac pathology.
Does endothelin-1 mediate cardiac mast cell degranulation and matrix metalloproteinase activation in isolated rat hearts?
Endothelin-1 acts as a potent cardiac mast cell secretagogue, mediating mast cell degranulation and MMP activation, which may contribute to myocardial remodeling.
Murray et al. (2004) studied this question.
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