What is the clinical evidence from this study?

Study design: Review. Population: Adverse myocardial remodelling. Intervention: Cardiac mast cells.

What question did this study set out to answer?

To evaluate the regulatory mechanisms and dual roles of cardiac mast cells in directing matrix metalloproteinase activation, extracellular matrix degradation, and fibrosis in the diseased heart.

August 24, 2010Cardiovascular ResearchOpen Access

Cardiac mast cells: the centrepiece in adverse myocardial remodelling

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Key result

Cardiac mast cells play dual roles in adverse myocardial remodelling by activating matrix metalloproteinases to cause collagen degradation and promoting fibrosis in the stressed or diseased heart.

Population

Human hearts with dilated cardiomyopathy and animal models of experimentally induced hypertension…

Design

Review

Authors

SLScott P. LevickWest Virginia University GMGiselle C. MeléndezWake Forest University ÉPÉric PlanteSUNY Upstate Medical University

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Implication

Mast cell modulation may offer a novel remodeling target; leaves open net benefit and optimal strategies in human heart disease.

Key Points

To evaluate the regulatory mechanisms and dual roles of cardiac mast cells in directing matrix metalloproteinase activation, extracellular matrix degradation, and fibrosis in the diseased heart.
Synthesized findings from human explanted hearts with dilated cardiomyopathy and experimental animal models of hypertension, myocardial infarction, and chronic volume overload.
Evaluated mechanistic data from in vitro protease activation assays, mast cell-deficient rodent models, and pharmacological inhibition of mast cell degranulation.
Mast cell density rises alongside chronic ventricular volume overload, activating matrix metalloproteinases (collagenases, gelatinases, stromelysin) that accelerate fibrillar collagen degradation.
Mast cells assume a distinct pro-fibrotic phenotype in hypertension and cardiac transplantation models, whereas mast cell-deficient or degranulation-inhibited rodents are protected from these adverse structural events.
Sex-specific functional differences in cardiac mast cells contribute to the cardioprotective phenotype observed in premenopausal females.

Structured PICO

Population

Human hearts with dilated cardiomyopathy and animal models of experimentally induced hypertension, myocardial infarction, and chronic volume overload

This review highlights the central, dual role of cardiac mast cells in driving both extracellular matrix degradation and fibrosis during adverse myocardial remodeling.

Cite This Study

Levick et al. (2010) conducted a review in Adverse myocardial remodelling. Cardiac mast cells was evaluated. Cardiac mast cells play dual roles in adverse myocardial remodelling by activating matrix metalloproteinases to cause collagen degradation and promoting fibrosis in the stressed or diseased heart.

synapsesocial.com/papers/6a11c63635a4eec8fedcd05a https://doi.org/10.1093/cvr/cvq272

Topics

Heart transplantation Heart failure HFrEF treatment Hypertension management Myocarditis Women and heart disease

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Cardiac mast cells: the centrepiece in adverse myocardial remodelling

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Cardiac mast cells: the centrepiece in adverse myocardial remodelling

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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