Population
Adult rat ventricular cardiocytes cocultured with epicardial mesothelial cells (EMC)
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether epicardial ET-1 contributes to human hypertrophy.
Epicardial mesothelial cells synthesize and release endothelin-1, which is stimulated by Angiotensin II, suggesting a paracrine role in cardiac hypertrophy.
Eid et al. (1994) studied this question.
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