What does this research mean for the field?

Inhibition of ET(A) receptors prevents matrix metalloproteinase (MMP) activation and left ventricular dilation, demonstrating that endothelin contributes to chronic post-myocardial infarction remodeling through its effects on MMP activity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 2001AJP Heart and Circulatory Physiology

ETA-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat

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Why the study?

Does sitaxsentan prevent matrix metalloproteinase activation and left ventricular dilation in rats post-myocardial infarction?

Population

Rats, 3 days post-myocardial infarction (n=24)

Comparison

Sitaxsentan for 6 weeks vs Control group

Design

Preclinical, randomized

Follow-up

6 weeks

Authors

BPBruno K. PodesserAustrian Cluster for Tissue Regeneration DSDeborah A. SiwikBoston University FEFranz R. EberliInterventional Cardiology

Discussion

Member takes

Implication

Should not alter post-MI care; hypothesis-generating for ETA blockade limiting experimental remodeling.

Structured PICO

Does sitaxsentan prevent matrix metalloproteinase activation and left ventricular dilation in rats post-myocardial infarction?

Population

Rats, 3 days post-myocardial infarction (n=24)

Intervention

Sitaxsentan (ETA-selective receptor antagonist) for 6 weeks

Comparator

Control group

Outcome

Left ventricular end-diastolic and end-systolic pressure-volume relationships and myocardial MMP-1, MMP-2, and MMP-9 activities at 6 weekssurrogate

Inhibition of ETA receptors with sitaxsentan prevents MMP activation and left ventricular dilation in a rat model of post-myocardial infarction remodeling.

Cite This Study

Podesser et al. (2001) studied this question.

synapsesocial.com/papers/6a145e3d7753e742da59df32 https://doi.org/10.1152/ajpheart.2001.280.3.h984

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ETA-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ETA-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider