March 1, 2001The Medical Journal of Australia
Non‐valvular atrial fibrillation and stroke prevention
Why the study?
Does warfarin or aspirin reduce the risk of stroke in patients with non-valvular atrial fibrillation?
Population
Patients with non-valvular atrial fibrillation (chronic AF)
Design
Review
Authors
Discussion
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Member takes
Implication
Balances stroke reduction against hemorrhage risk in AF; leaves open net benefit versus NOACs in contemporary practice.
Structured PICO
Does warfarin or aspirin reduce the risk of stroke in patients with non-valvular atrial fibrillation?
P
Population
Patients with non-valvular atrial fibrillation (chronic AF)
I
Intervention
Warfarin (target INR 2.0-3.0) or aspirin
O
Outcome
Stroke and major hemorrhagehard clinical
Warfarin is highly effective for stroke prevention in non-valvular atrial fibrillation, reducing risk by approximately two-thirds, though its use must be balanced against the risk of major hemorrhage.
Cite This Study
Graeme J. Hankey (2001) studied this question.