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April 23, 2008Journal of Biological ChemistryOpen Access

Systematic Deletion of the Adenovirus-associated RNAI Terminal Stem Reveals a Surprisingly Active RNA Inhibitor of Double-stranded RNA-activated Protein Kinase

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Population

In vitro biochemical models of adenovirus-associated RNA and double-stranded RNA-activated protein kinase

Comparison

Progressive deletion of the VA RNA terminal… vs Wild-type VA RNA(I)

Design

Preclinical

Authors

AWAhmed WahidAlexandria UniversityVCVeronica K. CoventryEmory UniversityGCGraeme L. ConnEmory University

Discussion

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Implication

Terminal stem dispensability may enable mini-RNA antiviral designs; leaves open in vivo validation before any therapeutic consideration.

Structured PICO

P
Population
In vitro biochemical models of adenovirus-associated RNA(I) and double-stranded RNA-activated protein kinase (PKR)
I
Intervention
Progressive deletion of the VA RNA(I) terminal stem, including the TSDelta21 RNA mutant
C
Comparator
Wild-type VA RNA(I)
O
Outcome
PKR inhibitory activity and binding thermodynamicssurrogate

The terminal stem of adenovirus VA RNA(I) is dispensable for PKR inhibition, suggesting a bi-functional role where Dicer processing leaves a fully active mini-RNA.

Cite This Study

Wahid et al. (2008) studied this question.

synapsesocial.com/papers/6a72dc99da24de05641ae57dhttps://doi.org/10.1074/jbc.m802300200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structural features of adenovirus 2 virus-associated RNA required for binding to the protein kinase DAI1994 · 34 citations
  2. 2Analysis of adenovirus VA RNA I structure and stability using compensatory base pair modifications2008 · 21 citations
  3. 3Comparative analysis of the structure and function of adenovirus virus-associated RNAs1993 · 56 citations
  4. 4Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function.1991 · 61 citations
  5. 5Binding of Epstein-Barr virus small RNA EBER-1 to the double-stranded RNA-activated protein kinase DAI1991 · 163 citations