Population
Adenovirus VA RNA(I) (wild-type and six sets of mismatch and compensatory base pair mutants)
Comparison
Mismatch and compensatory base pair modifications vs Wild-type VA RNA(I)
Design
Preclinical
Authors
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These folding and mutational data refine VA RNA(I)–PKR interactions; leaves open therapeutic targeting in human innate-immunity disorders.
The study validates the secondary structure model of adenovirus VA RNA(I) and identifies a Central Domain component essential for PKR inhibition.
Coventry et al. (2008) studied this question.
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