Why the study?
Does neuropeptide Y potentiate noradrenergic vasoconstriction in human saphenous veins via endothelium-derived thromboxane?
Population
Human saphenous vein rings (ex vivo model)
Comparison
Neuropeptide Y (NPY) 50 nM vs Absence of NPY, endothelium-denuded vessel…
Design
Preclinical
Authors
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Supports TxA2-dependent NPY potentiation of venous tone in animals; leaves open relevance to human saphenous veins.
Does neuropeptide Y potentiate noradrenergic vasoconstriction in human saphenous veins via endothelium-derived thromboxane?
Neuropeptide Y potentiates sympathetic vasoconstriction in human saphenous veins through the release of endothelium-derived thromboxane A2.
Fabi et al. (1998) studied this question.
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