March 1, 1999British Journal of PharmacologyOpen Access

Adenosine 5′‐triphosphate and neuropeptide Y are co‐transmitters in conjunction with noradrenaline in the human saphenous vein

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Population

Human saphenous vein rings from recently dissected human biopsies

Design

Preclinical

Authors

HRHéctor RacchiPontificia Universidad Católica de Chile MIM.J. IrarrazabalPontificia Universidad Católica de Chile MHMichel HowardPontificia Universidad Católica de Chile

Discussion

Member takes

Implication

Supports triple co-transmission in sympathetic vasomotor control; leaves open translation to human in vivo physiology.

Structured PICO

Population

Human saphenous vein rings from recently dissected human biopsies

Intervention

Electrical depolarization (2.5-20 Hz, 50 V, 0.5 msec) and application of ATP, neuropeptide Y (NPY), noradrenaline (NA), and various antagonists (suramin, prazosin, BIBP 3226)

Outcome

Isometric muscular contractions (vasomotor responses) in the circular muscle layersurrogate

The study demonstrates that ATP, neuropeptide Y, and noradrenaline act as co-transmitters in human sympathetic vasomotor reflexes in the saphenous vein.

Cite This Study

Racchi et al. (1999) studied this question.

synapsesocial.com/papers/6a83f737a91c8d236ee665ba https://doi.org/10.1038/sj.bjp.0702396

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Adenosine 5′‐triphosphate and neuropeptide Y are co‐transmitters in conjunction with noradrenaline in the human saphenous vein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenosine 5′‐triphosphate and neuropeptide Y are co‐transmitters in conjunction with noradrenaline in the human saphenous vein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider