Why the study?
Does yohimbine or prazosin inhibit stimulation-evoked contractions in human isolated saphenous veins?
Does yohimbine or prazosin inhibit stimulation-evoked contractions in human isolated saphenous veins?
Neuro-effector transmission in human saphenous vein is mediated predominantly by postjunctional alpha 2-adrenoceptors, as evidenced by the high potency of yohimbine compared to prazosin.
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Highlights α2 predominance in venous neurotransmission; leaves open any clinical translation for selective antagonists.
Docherty et al. (1985) studied this question.
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