Key result
Local infusion of prazosin and yohimbine caused dose-dependent reductions in noradrenaline-induced venoconstriction in the human saphenous vein.
Why the study?
Do alpha-adrenoceptor subtype-selective antagonists prazosin and yohimbine reduce noradrenaline-induced venoconstriction in the human saphenous vein in vivo?
Population
n=6 healthy male subjects
Authors
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Both α1- and α2-adrenoceptors mediate saphenous venoconstriction; extends receptor mapping but remains hypothesis-generating.
Do alpha-adrenoceptor subtype-selective antagonists prazosin and yohimbine reduce noradrenaline-induced venoconstriction in the human saphenous vein in vivo?
The human saphenous vein contains functionally important populations of both alpha 1- and alpha 2-adrenoceptors that mediate venoconstriction.
Steen et al. (1986) studied Healthy (n=6). Prazosin and yohimbine was evaluated on Reduction of noradrenaline-induced venoconstriction. Local infusion of prazosin and yohimbine caused dose-dependent reductions in noradrenaline-induced venoconstriction in the human saphenous vein.
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