Why the study?
Viral and host factors contribute to intra-host variability in SARS-CoV-2, which can be captured via next-generation sequencing as intra-host single nucleotide variations to aid tracking and early variant identification.
Population
1, 347 SARS-CoV-2 samples collected till June 2020 and 1, 798 samples sequenced in India
Design
Genomic sequencing and intra-host variation analysis
Authors
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Extensive early-pandemic iSNV catalog leaves open intra-host drivers of VOC emergence; larger longitudinal studies required.
Tracking intra-host single nucleotide variations in SARS-CoV-2 genomes can serve as an early warning system for identifying emerging variants of concern.
Pathak et al. (2020) studied this question.
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