Key result
Tracking of intra-host single nucleotide variations in SARS-CoV-2 genomes showed that ~80% of iSNV sites were later reported as fixed SNVs in the population by June 2021.
Population
1347 samples collected till June 2020 and 1774 samples sequenced in India between November 2020 and May 2021
Design
Genome sequencing and intra-host variation analysis
Authors
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iSNV tracking may flag emerging variants early; leaves open its integration into routine surveillance.
Observational (n=3,121)
Tracking intra-host single nucleotide variations in SARS-CoV-2 genomes can serve as an early warning system for identifying potential variants of concern before they become fixed in the population.
Pathak et al. (2022) conducted an observational in SARS-CoV-2 infection (n=3,121). Intra-host single nucleotide variations (iSNVs) was evaluated on Transition of iSNV sites to reported SNVs in consensus sequences. Tracking of intra-host single nucleotide variations in SARS-CoV-2 genomes showed that ~80% of iSNV sites were later reported as fixed SNVs in the population by June 2021.