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January 1, 1991International Journal of Gynecology & Obstetrics

Heparin therapy for pregnant women with lupus anticoagulant or anticardiolipin antibodies

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Why the study?

Does full-dose subcutaneous heparin therapy improve the rate of live births in pregnant women with lupus anticoagulant or anticardiolipin antibodies and prior pregnancy losses?

Population

14 pregnant women with lupus anticoagulant or anticardiolipin antibodies, with a history of one or more…

Design

Case_series

Follow-up

Until delivery

Authors

MRM RosoveUniversity of California, Los AngelesKTKhalil TabshUniversity of California, Los AngelesNWNathan WasserstrumBaylor University

Discussion

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Implication

Supports heparin in select antiphospholipid pregnancies; leaves open efficacy pending randomized trials.

Structured PICO

Does full-dose subcutaneous heparin therapy improve the rate of live births in pregnant women with lupus anticoagulant or anticardiolipin antibodies and prior pregnancy losses?

P
Population
14 pregnant women with lupus anticoagulant or anticardiolipin antibodies, with a history of one or more abnormal pregnancy outcomes (total 28 losses, one severely growth-retarded premature live-born) and no normal outcomes.
I
Intervention
Full-dose, subcutaneous, twice-daily heparin therapy (mean total daily dosage 24,700 +/- 7400 units) started at an estimated gestational age of 10.3 +/- 4.0 weeks.
O
Outcome
Live birthhard clinical

Full-dose subcutaneous heparin therapy resulted in a high rate of live births in pregnant women with lupus anticoagulant or anticardiolipin antibodies and a history of recurrent pregnancy loss.

Cite This Study

Rosove et al. (1991) studied this question.

synapsesocial.com/papers/6a72dd95b0d581bd9f303f24https://doi.org/10.1016/0020-7292(91)90548-j
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Timing of initiation of low-molecular-weight heparin administration in pregnant women with antiphospholipid syndrome: a randomized clinical trial of efficacy and safety2019 · 13 citations
  2. 2Assessment of pregnancy outcome with low molecular weight heparin therapy: a retrospective, single centre observational study2018 · 1 citations
  3. 3Low‐molecular‐weight heparin for thrombophilia in pregnant women2000 · 39 citations
  4. 4Heparin Therapy During Pregnancy1989 · 204 citations
  5. 5Inherited Thrombophilia: Treatment during Pregnancy2006 · 18 citations