October 1, 1989Archives of Internal Medicine
Heparin Therapy During Pregnancy
Why the study?
Is heparin therapy safe for the mother and fetus during pregnancy?
Population
100 pregnancies in 77 women treated with heparin during pregnancy
Comparison
Heparin therapy vs Normal population (for fetal outcomes)
Design
Cohort
Follow-up
During pregnancy
Authors
Discussion
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Member takes
Implication
Supports heparin in pregnancy; observational data leave open need for randomized confirmation before changing practice.
Structured PICO
Is heparin therapy safe for the mother and fetus during pregnancy?
P
Population
100 pregnancies in 77 women treated with heparin during pregnancy (98 for prevention or treatment of venous thromboembolism, 2 for prosthetic heart valves)
I
Intervention
Heparin therapy
C
Comparator
Normal population (for fetal outcomes)
O
Outcome
Fetal outcomes (prematurity, abortions, stillbirths, neonatal deaths, congenital abnormalities) and maternal outcomes (bleeding episodes, symptomatic thrombotic episodes)safety
Heparin therapy during pregnancy appears safe for the fetus and is associated with an acceptable maternal bleeding rate and low thrombotic recurrence.
Cite This Study
Jeffrey S. Ginsberg (1989) studied this question.