Why the study?
Are skin collagen advanced glycation endproducts associated with the long-term progression of subclinical cardiovascular disease in patients with type 1 diabetes?
Are skin collagen advanced glycation endproducts associated with the long-term progression of subclinical cardiovascular disease in patients with type 1 diabetes?
In type 1 diabetes, multiple skin collagen AGEs are associated with IMT progression and cardiac MRI outcomes, while early glycation (furosine) is associated with CAC score, suggesting a role of glycation in matrix accumulation.
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Skin AGEs may associate with subclinical CVD; leaves open added value beyond glycemia for risk prediction.
Monnier et al. (2015) studied this question.
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