An individual patient-based meta-analysis of the effects of dronedarone in patients with atrial fibrillation
Why the study?
Does dronedarone affect cardiovascular death and hospitalization in patients with atrial fibrillation?
Population
9,664 patients with atrial fibrillation from all placebo-controlled studies
Comparison
Dronedarone vs Placebo
Design
Meta-analysis
Authors
Discussion
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Member takes
Implication
Avoid dronedarone in permanent AF; confirms harm and restricts benefit to non-permanent AF.
Structured PICO
Does dronedarone affect cardiovascular death and hospitalization in patients with atrial fibrillation?
P
Population
9,664 patients with atrial fibrillation from all placebo-controlled studies
I
Intervention
Dronedarone
C
Comparator
Placebo
O
Outcome
Cardiovascular deathhard clinical
Dronedarone is harmful in patients with permanent atrial fibrillation, increasing cardiovascular death and heart failure hospitalization, but provides benefit in reducing cardiovascular hospitalizations in non-permanent AF.
Cite This Study
Hohnloser et al. (2014) studied this question.